Renal dosing of Levofloxacin

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Levofloxacin - Dose adjustment for renal impairment

Cockcroft-Gault CrCl estimates (using the creatinine clearance calculator) should be used for drug dosing rather than the automated MDRD eGFR produced by the clinical chemistry laboratory available on NOTIS.

CrCl (ml/min)	Dose
20-50	500mg stat then 250mg bd*
10-20	500mg stat then 125mg bd*
<10	500mg stat then 125mg od

* Applies if full dose is 500mg bd. If full dose is 500mg od, give reduced dose once daily.

As Levofloxacin can increase selection for C.difficile infection and MRSA colonisation/infection, all patients with previous MRSA/C.difficile require documented microbiology approval regardless of indication.

Refer to renal pharmacist for advice on dosing in haemodialysis and peritoneal dialysis.

Refer to critical care pharmacist for advice on dosing in CVVH.

Page last edited: 09/10/2009

Caution; the antibiotic doses recommended on this website are intended for adult patients with normal renal and liver function unless otherwise stated. Dosing advice for patients with renal impairment is available here.